Glycine, a simple physiological compound protecting by yet puzzling mechanism(s) against ischaemia-reperfusion injury: current knowledge
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چکیده
منابع مشابه
New directions for protecting the heart against ischaemia-reperfusion injury: targeting the Reperfusion Injury Salvage Kinase (RISK)-pathway.
Reperfusion is a pre-requisite to salvaging viable myocardium, following an acute myocardial infarction. Reperfusion of ischaemic myocardium, however, is not without risk, as the act of reperfusion itself can paradoxically result in myocyte death: a phenomenon termed lethal reperfusion-induced injury. Therapeutic strategies that target and attenuate reperfusion-induced cell death may provide no...
متن کاملEditorial: Molecular Mechanisms Protecting against Tissue Injury
In response to tissue injury acute inflammatory reactions occur that aim to restore homeostasis (Medzhitov, 2008). However, hampered resolution of inflammation can result in chronic inflammation and/or pathologic wound repair (Nathan and Ding, 2010). These conditions can result from excessive oxidative and inflammatory and/or overwhelmed adaptive response systems. They may also be triggered by ...
متن کاملStobadine protects rat kidney against ischaemia/reperfusion injury.
1. Ischaemia-reperfusion (I/R) injury, one of the main causes of acute renal failure, still needs satisfactory treatment for routine clinical application. Stobadine, a novel synthetic pyridoindole anti-oxidant, has the ability to reduce tissue injury induced by mechanisms involving reactive oxygen species during I/R. The aim of the present study was to determine the effects of stobadine on rena...
متن کاملPharmacological interventions against myocardial ischaemia and reperfusion injury
Background: Although the concept of early restoration of coronary bloodflow constitutes an important factor to reduce the injury caused by myocardial ischaemia, reperfusion in itself can aggravate the damage to myocardial tissue, a phenomenon denoted myocardial reperfusion injury. Aims: To investigate whether two different pharmacological interventions, cyclosporine A (CsA) and the novel enkeph...
متن کاملTrimetazidine and liver preservation against ischaemia-reperfusion injury
Trimetazidine is an anti-ischaemic drug used for angina pectoris treatment. Recently, it has been shown that trimetazidine protects against hepatic ischaemia reperfusion injury. Several hypotheses have been proposed to explain the exact hepatoprotective mechanisms but they still remain unclear. This review assesses the possible mechanisms responsible for the increase of the liver’s tolerance ag...
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ژورنال
عنوان ژورنال: British Journal of Pharmacology
سال: 2012
ISSN: 0007-1188
DOI: 10.1111/j.1476-5381.2011.01711.x